Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study
نویسندگان
چکیده
منابع مشابه
A Quantitative Structure-Activity Relationship Study of Caffeic Acid Amides as Selective Inhibitors of Matrix Metalloproteinase
Introduction Matrix metalloproteinases (MMPs) represent a family of zinc dependent endopeptidases which is involved in the breakdown of components of the extracellular matrix and helps in tissue remodeling [1]. The process is vital in embryonic development, pregnancy, growth and wound healing. Usually the activity of MMPs is restricted by the equilibrium between synthesis of active MMPs and the...
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Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
متن کاملTwo Matrix Metalloproteinase Inhibitors from Scrophularia Striata Boiss
Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...
متن کاملAltered endochondral bone development in matrix metalloproteinase 13-deficient mice.
The assembly and degradation of extracellular matrix (ECM) molecules are crucial processes during bone development. In this study, we show that ECM remodeling is a critical rate-limiting step in endochondral bone formation. Matrix metalloproteinase (MMP) 13 (collagenase 3) is poised to play a crucial role in bone formation and remodeling because of its expression both in terminal hypertrophic c...
متن کاملDevelopment of matrix metalloproteinase inhibitors in cancer therapy.
The matrix metalloproteinases represent an attractive target for cancer treatment, and a number of matrix metalloproteinase inhibitors are undergoing clinical trials. The results of these studies will establish whether any of these compounds are therapeutically useful. Independent of the conclusions from the first generation of studies, the field of matrix metalloproteinase inhibitors remains a...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2018
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2018.08.020